(R)-Gyramide A hydrochloride

Names

[ Name ]:
(R)-Gyramide A hydrochloride

[Synonym ]:
5-Fluoro-N-[(3R)-1-(4-isopropoxybenzyl)-3-pyrrolidinyl]-2-methylbenzenesulfonamide hydrochloride (1:1)
Benzenesulfonamide, 5-fluoro-2-methyl-N-[(3R)-1-[[4-(1-methylethoxy)phenyl]methyl]-3-pyrrolidinyl]-, hydrochloride (1:1)

Biological Activity

[Description]:

(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈ClFN₂O₃S

[ Molecular Weight ]:
442.975

[ Exact Mass ]:
442.149323

Related Compounds

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