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3-Hydroxybakuchiol

Names

[ CAS No. ]:
178765-54-3

[ Name ]:
3-Hydroxybakuchiol

[Synonym ]:
4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadien-1-yl]-1,2-benzenediol
1,2-Benzenediol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-

Biological Activity

[Description]:

3-Hydroxybakuchiol can be isolated from Otholobium mexicanum J. W. Grimes. 3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor. 3-Hydroxybakuchiol has antitumor activity, and induces tumor cell apoptosis. 3-Hydroxybakuchiol also has moderate inhibitory activity against α-glucosidase (IC50: 345 μM)[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Jaña F, et al. Tumor cell death induced by the inhibition of mitochondrial electron transport: the effect of 3-hydroxybakuchiol. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):356-64.  

[2]. Suárez AI, et al. Main Constituents and Antidiabetic Properties of Otholobium mexicanum. Nat Prod Commun. 2017 Apr;12(4):533-535.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
437.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H24O2

[ Molecular Weight ]:
272.382

[ Flash Point ]:
200.4±23.3 °C

[ Exact Mass ]:
272.177643

[ PSA ]:
40.46000

[ LogP ]:
5.95

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.574

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds