Raloxifene 6-Monomethyl Ether

Names

[ Name ]:
Raloxifene 6-Monomethyl Ether

Biological Activity

[Description]:

Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC50 of 250 nM and a pIC50 of 6.6[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

[In Vitro]

Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative with a methoxy group on C6. Raloxifene 6-Monomethyl Ether holds poor ICsub>50 value because of disruption to the hydrogen bond network and steric disfavor[1].

[References]

[1]. Chang YH, et al. Computational study of estrogen receptor-alpha antagonist with three-dimensional quantitative structure-activity relationship, support vector regression, and linear regression methods. Int J Med Chem. 2013;2013:743139.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₉NO₄S

[ Molecular Weight ]:
487.61

Related Compounds

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