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C 021 dihydrochloride

Names

[ CAS No. ]:
1784252-84-1

[ Name ]:
C 021 dihydrochloride

[Synonym ]:
MFCD16618393
2-(1,4'-Bipiperidin-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride
2-(1,4'-Bipiperidin-1'-yl)-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-, hydrochloride (1:2)

Biological Activity

[Description]:

C-021 dihydrochloride is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.

[References]

References 1. Yokoyama K, et al. Bioorg Med Chem. 2009 Jan 1;17(1):64-73. View Related Products by Target Chemokine Receptor (CCR and CXCR)

Chemical & Physical Properties

[ Molecular Formula ]:
C27H41N5O2.2HCl

[ Molecular Weight ]:
540.569

[ Exact Mass ]:
539.279358

[ Storage condition ]:
2-8°C

Related Compounds