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1,23-Dibromo-3,6,9,12,15,18,21-heptaoxatricosane

Names

[ CAS No. ]:
177987-04-1

[ Name ]:
1,23-Dibromo-3,6,9,12,15,18,21-heptaoxatricosane

[Synonym ]:
3,6,9,12,15,18,21-Heptaoxatricosane, 1,23-dibromo-
1,23-Dibromo-3,6,9,12,15,18,21-heptaoxatricosane

Biological Activity

[Description]:

Br-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
486.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H32Br2O7

[ Molecular Weight ]:
496.229

[ Flash Point ]:
203.4±25.8 °C

[ Exact Mass ]:
494.051453

[ LogP ]:
-0.28

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.483

Related Compounds