3,4,5-Trihydroxycinnamic acid decyl ester

Names

[ Name ]:
3,4,5-Trihydroxycinnamic acid decyl ester

Biological Activity

[Description]:

3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

EC50: 0.9 μM (pancreatic lipase)[1]

[In Vitro]

3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro[1]. 3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC50 value being approximately 0.9 μM[1]. 3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation[1].

[In Vivo]

3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally[1]. Animal Model: 6 weeks old Male ddY mice[1] Dosage: 30 mg/kg, 150 mg/kg Administration: Oral administration Result: Reduced plasma TG in a dose-dependent manner.

[References]

[1]. Masahiko Imai ,et al. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorg Med Chem. 2015 Jul 1;23(13):3788-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₈O₅

[ Molecular Weight ]:
336.42

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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