BMS-193884

Names

[ Name ]:
BMS-193884

Biological Activity

[Description]:

BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

[Target]

ETA:1.4 nM (Ki)

ETB:18700 nM (Ki)

[References]

[1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₇N₃O₄S

[ Molecular Weight ]:
395.43200

[ Exact Mass ]:
395.09400

[ PSA ]:
106.61000

[ LogP ]:
5.56800

Synthetic Route

Click to get detail synthetic route

Related Compounds

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