Lanatoside B

Names

[ CAS No. ]:
17575-21-2

[ Name ]:
Lanatoside B

[Synonym ]:
Lanatosid-B
LANTOSIDEB
digilanidb
Digilanide B

Biological Activity

[Description]:

Lanatoside B is a cardenolide that can be isolated from the leaves of Digitalis lanata[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Fernão Castro Braga, et al. Variation of cardenolides with growth in a Digitalis lanata Brazilian cultivar. Phytochemistry, 45 (3), 1997, 473-476.

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Melting Point ]:
245-248ºC

[ Molecular Formula ]:
C₄₉H₇₆O₂₀

[ Molecular Weight ]:
985.12

[ Exact Mass ]:
984.49300

[ PSA ]:
288.28000

[ LogP ]:
0.61310

[ Index of Refraction ]:
1.608

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OE2040000

CHEMICAL NAME :: Lanatoside B

CAS REGISTRY NUMBER :: 17575-21-2

BEILSTEIN REFERENCE NO. :: 0078394

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C49-H76-O20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 177,60,1934

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 388 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 31,236,1942

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3695 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 252,314,1966 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,52,1963