BPIQ-I

Names

[ Name ]:
BPIQ-I

[Synonym ]:
HMS3229C05
8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline
Imidazoquinazoline deriv. 12
IN1402
bpiq-i

Biological Activity

[Description]:

BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vitro]

BPIQ-I (0-50 µM; 3 days) 具有抗增殖活性，对 A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 细胞的 EC50 值分别为 >50、30、>50、6.5、>50 µM [1]. BPIQ-I (10 nM) 通过与 ATP 竞争来阻断 erbB RTK，从而消除 CO2 敏感性[2]。 Cell Viability Assay [1] Cell Line: A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells Concentration: 0-50 µM Incubation Time: 3 days Result: Inhibited cells growth with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively.

[References]

[1]. Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107.

[2]. Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂BrN₅

[ Molecular Weight ]:
354.20400

[ Exact Mass ]:
353.02800

[ PSA ]:
55.63000

[ LogP ]:
4.09560

Related Compounds

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