2-Amino-6-methoxybenzothiazole
Names
[ CAS No. ]:
1747-60-0
[ Name ]:
2-Amino-6-methoxybenzothiazole
[Synonym ]:
2-Amino-6-methoxybenzothiazole
6-Methoxy-1,3-benzothiazol-2-amine
6-Methoxy-2-aminobenzothiazole
2-Benzothiazolamine, 6-methoxy-
EINECS 217-130-0
MFCD00005787
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
347.5±34.0 °C at 760 mmHg
[ Melting Point ]:
165-167 °C(lit.)
[ Molecular Formula ]:
C8H8N2OS
[ Molecular Weight ]:
180.227
[ Flash Point ]:
163.9±25.7 °C
[ Exact Mass ]:
180.035736
[ PSA ]:
76.38000
[ LogP ]:
1.81
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.705
[ Stability ]:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
<0.1 g/100 mL at 21 ºC
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DL2100000
- CHEMICAL NAME :
- Benzothiazole, 2-amino-6-methoxy-
- CAS REGISTRY NUMBER :
- 1747-60-0
- BEILSTEIN REFERENCE NO. :
- 0131202
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H8-N2-O-S
- MOLECULAR WEIGHT :
- 180.24
- WISWESSER LINE NOTATION :
- T56 BN DSJ CZ GO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn,Xi
[ Risk Phrases ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[ Safety Phrases ]:
S26
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
DL2100000
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Saudi Pharm. J. 18(3) , 129-36, (2010)
A novel series of Schiff bases 5a-j and 4-thiazolidinones 6a-j have been prepared from the building blocks 2-chloro pyridine-3-carboxylic acid [1] and 2-amino-6-methoxy-benzothiazole [2]. All of the s...
Effect of Aroclor 1254 dose upon S9 activation of aromatic amine bacterial mutagens.Mutat. Res. 77(4) , 361-6, (1980)
Structural, vibrational, electronic investigations and quantum chemical studies of 2-amino-4-methoxybenzothiazole.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 102 , 327-40, (2013)
Extensive vibrational investigations of 2-amino-4-methoxybenzothiazole have been carried out with FTIR and FT-Raman spectral techniques. The electronic structure of the molecule has been analysed by U...