Dimethylaminopropionitrile
Names
[ CAS No. ]:
1738-25-6
[ Name ]:
Dimethylaminopropionitrile
[Synonym ]:
2-DIMETHYLAMINOETHYL CYANIDE
Cyanogum41catalyst
MFCD00001957
3-(Dimethylamino)propanenitrile
3-(DIMETHYLAMINO)PROPIONITRILE
EINECS 217-090-4
Dimethylaminopropion
3-(N,N-dimethylamino)-propionitrile
3-dimethylaminopropannitril
3-(dimethylamino)-propionitril
2-Dimthylaminoethyl cyanide
DMAPN
3-Dimethylaminopropanonitrile
β-Dimethylaminopropionitrile
Chemical & Physical Properties
[ Density]:
0.87 g/mL at 25 °C(lit.)
[ Boiling Point ]:
171 °C750 mm Hg(lit.)
[ Melting Point ]:
−43 °C(lit.)
[ Molecular Formula ]:
C5H10N2
[ Molecular Weight ]:
98.14630
[ Flash Point ]:
145 °F
[ Exact Mass ]:
98.08440
[ PSA ]:
27.03000
[ LogP ]:
0.46168
[ Vapour Pressure ]:
1.24mmHg at 25°C
[ Index of Refraction ]:
n20/D 1.426(lit.)
[ Water Solubility ]:
0.5 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UG1575000
- CHEMICAL NAME :
- Propionitrile, 3-(dimethylamino)-
- CAS REGISTRY NUMBER :
- 1738-25-6
- BEILSTEIN REFERENCE NO. :
- 0773779
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C5-H10-N2
- MOLECULAR WEIGHT :
- 98.17
- WISWESSER LINE NOTATION :
- NC2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,923,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,923,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2600 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,923,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00201
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1410 uL/kg
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIMETHYLAMINOPROPIONITRILE-air:min expos to NIAX REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3293 No. of Facilities: 145 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1990 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312-H319
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R21;R36/38
[ Safety Phrases ]:
S26-S36/37-S24/25
[ RIDADR ]:
2927
[ WGK Germany ]:
1
[ RTECS ]:
UG1575000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
29269095
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Toxicol. Appl. Pharmacol. 110(1) , 61-9, (1991)
The urotoxicity and metabolism of N,N'-dimethylaminopropionitrile (DMAPN) were investigated in male Sprague-Dawley rats. Animals treated with 525 mg DMAPN/kg or equimolar doses of commercially availab...
Purification of RNA molecules by gel techniques.Meth. Enzymol. 180 , 14-25, (1989)
[Morbidity study of employees exposed to dimethylaminopropionitrile].
Zentralbl. Arbeitsmed. Arbeitsschutz. Prophyl. Ergonomie 32(5) , 181-4, (1982)