Human PTHrP-(1-36)

Names

[ CAS No. ]:
172867-62-8

[ Name ]:
Human PTHrP-(1-36)

Biological Activity

[Description]:

Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism[1][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Human PTHrP-(1-36) (EC50: 0.05 nM) increases intracellular calcium in human epidermal keratinocytes[2]. Human PTHrP-(1-36) (100 nM, 24 h) increases human β-cell proliferation[3]. Human PTHrP-(1-36) (100 nM, 30 min) enhances insulin secretion in human islets[3]. PTHrP-(1-36) (mouse, EC50: 1 nM) induces a rapid Ca2+ response in UMR 106 cells[4].

[In Vivo]

PTHrP-(1-36) (mouse, 160 μg/kg, s.c., for 5 days/week for 7, 30, or 90 days) enhances beta cell regeneration and increases beta cell mass in a mouse model of partial pancreatectomy[5]. PTHrP-(1-36) (mouse, 100 μg/kg, s.c., every other day) reverses the observed decrease of Wisp1 expression in the diabetic mice[6].

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.