Frunevetmab

Names

[ Name ]:
Frunevetmab

Biological Activity

[Description]:

Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

Kd: 20 pM (NGF)[2]

[In Vitro]

Frunevetmab (NV-02) neutralizes NGF with high affinity and potency and does not bind complement[2].

[In Vivo]

Frunevetmab (1.0-2.8 mg/kg; s.c; on days 0, 28, and 56) shows positive treatment effects in cats with naturally-occurring OA pain and associated mobility impairment and disability[1]. Animal Model: Cats with naturally-occurring OA pain and associated mobility impairment and disability[1] Dosage: 1.0-2.8 mg/kg Administration: s.c; 3 times at 28-day intervals; on days 0, 28, and 56 Result: Reliefed the pain from osteoarthritis in cats.

[References]

[1]. Margaret E Gruen, et al. Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats. J Vet Intern Med. 2021 Nov;35(6):2752-2762.

[2]. D P Gearing, et al. In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats. J Vet Intern Med. 2016 Jul;30(4):1129-37.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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