Cyasterone

Names

[ Name ]:
Cyasterone

[Synonym ]:
(2β,3β,5β,22R,24S,25S,28R)-2,3,14,20,22-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione
(2β,3β,5β,23R,24ξ,25S,28R)-2,3,14,20,23-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione
Stigmast-7-ene-6,26-dione, 26,28-epoxy-2,3,14,20,23-pentahydroxy-, (2β,3β,5β,23R,24ξ,25S,28R)-
cyasteron
Stigmast-7-ene-6,26-dione, 26,28-epoxy-2,3,14,20,22-pentahydroxy-, (2β,3β,5β,22R,24S,25S,28R)-
Cyasterone

Biological Activity

[Description]:

Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae).Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a clinical therapeutic anti-tumor agent against human tumors[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vitro]

Cyasterone (0-100μM; 24hours) inhibits cell growth in a concentration-and time-dependent manner, IC50 values are 38.50 mg/mL, 32.96 mg/mL in A549 and MGC823 cells ,respectively[1]. Cell Viability Assay[1] Cell Line: A549, HCT116, MGC823 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited the growth of 3 human cancer lines A549, HCT116, MGC823 cells.

[References]

[1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
742.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₄₄O₈

[ Molecular Weight ]:
520.655

[ Flash Point ]:
242.0±26.4 °C

[ Exact Mass ]:
520.303589

[ PSA ]:
144.52000

[ LogP ]:
-0.25

[ Vapour Pressure ]:
0.0±5.6 mmHg at 25°C

[ Index of Refraction ]:
1.600

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WJ2510000

CHEMICAL NAME :: 5-beta-Stigmast-7-en-26-oic acid, 2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-, gamma- lactone, (22R,24S,25S,28R)-

CAS REGISTRY NUMBER :: 17086-76-9

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H44-O8

MOLECULAR WEIGHT :: 520.73

WISWESSER LINE NOTATION :: L E5 B666 LV JUTJ IQ OQ PQ FXQ1&YQ1YYQ1&Y1&- CT4OVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 300 umol/L

REFERENCE :: NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246, 1971-73. For publisher information, see NATUAS. Volume(issue)/page/year: 230,222,1971

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
WJ2510000

Related Compounds

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