11-Keto-beta-boswellic acid

Names

[ Name ]:
11-Keto-beta-boswellic acid

[Synonym ]:
11-keto-beta-Boswellic acid
(3α,5ξ,9ξ,18ξ)-3-Hydroxy-11-oxours-12-en-24-oic acid
11-KETO-β-BOSWELLIC ACID
Urs-12-en-24-oic acid, 3-hydroxy-11-oxo-, (3α,5ξ,9ξ,18ξ)-

Biological Activity

[Description]:

11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

NF-κB

[References]

[1]. Miscioscia E, et al. Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs. BMC Vet Res. 2019 Aug 1;15(1):270.

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
591.8ºC at 760mmHg

[ Molecular Formula ]:
C₃₀H₄₆O₄

[ Molecular Weight ]:
470.68400

[ Flash Point ]:
325.8ºC

[ Exact Mass ]:
470.34000

[ PSA ]:
74.60000

[ LogP ]:
6.26850

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.561

[ Storage condition ]:
2-8C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29189900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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