Sulfo-SPDP-C6-NHS sodium

Names

[ Name ]:
Sulfo-SPDP-C6-NHS sodium

[Synonym ]:
sodium 2,5-dioxo-1-[6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoyloxy]pyrrolidine-3-sulfonate
Sulfo-LC-SPDP
2,5-Dioxo-1-[[1-oxo-6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]hexyl]oxy]-3-pyrrolidinesulfonic Acid Monosodium Salt
Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate,Sodium Salt

Biological Activity

[Description]:

Sulfo-SPDP-C6-NHS sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Melting Point ]:
185-187ºC

[ Molecular Formula ]:
C₁₈H₂₂N₃NaO₈S₃

[ Molecular Weight ]:
527.56700

[ Exact Mass ]:
527.04700

[ PSA ]:
221.85000

[ LogP ]:
2.42910

[ Index of Refraction ]:
1.64

Related Compounds

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