CPA-7

A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells; selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors.

References 1. Turkson J, et al. Mol Cancer Ther. 2004 Dec;3(12):1533-42. 2. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. 3. Littlefield SL, et al. Inorg Chem. 2008 Apr 7;47(7):2798-804. 4. Liang M, et al. BMC Cancer. 2016 Jul 19;16:504. View Related Products by Target STAT