Tetrazine-Ph-PEG5-NHS ester

Names

[ Name ]:
Tetrazine-Ph-PEG5-NHS ester

[Synonym ]:
19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-N-[4-(1,2,4,5-tetrazin-3-yl)benzyl]-4,7,10,13,16-pentaoxanonadecan-1-amide
Tz-PEG5-NHS
4,7,10,13,16-Pentaoxanonadecan-1-amide, 19-[(2,5-dioxo-1-pyrrolidinyl)oxy]-19-oxo-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]-
MFCD28505547
Tetrazine-PEG5-NHS ester

Biological Activity

[Description]:

Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₇H₃₆N₆O₁₀

[ Molecular Weight ]:
604.609

[ Exact Mass ]:
604.249268

[ LogP ]:
-4.14

[ Index of Refraction ]:
1.570

Related Compounds

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