OSMI-1

Names

[ Name ]:
OSMI-1

[Synonym ]:
OSMI-1
(αR)-α-[[(1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide
OSMI 1
Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-
(2R)-N-(2-Furylmethyl)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydro-6-quinolinyl)sulfonyl]amino}-N-(2-thienylmethyl)acetamide

Biological Activity

[Description]:

OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM; inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans; also significantly decreases HSV replication.

[References]

References 1. Ortiz-Meoz RF, et al. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. 2. Angelova M, et al. J Virol. 2015 Aug;89(16):8474-83. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₂₅N₃O₆S₂

[ Molecular Weight ]:
563.645

[ Exact Mass ]:
563.118469

[ LogP ]:
4.32

[ Index of Refraction ]:
1.652

Related Compounds

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