Triptonine B

Names

[ Name ]:
Triptonine B

[Synonym ]:
Triptonine B
Methyl [(1S,2R,3R,4R,7S,11R,15R,16R,17R,18S,21S,22R,32R,34R,35S)-2,16,17,35-tetraacetoxy-21,34-dihydroxy-7,21,22,32,34-pentamethyl-6,10,12,20,29-pentaoxo-5,13,19,30,33-pentaoxa-26-azahexacyclo[16.15.1 ;.1.0.0.0]pentatriaconta-23,25,27-trien-11-yl]acetate

Biological Activity

[Description]:

Triptonine B, a sesquiterpene pyridine alkaloid that isolated from Tripterygium hypoglaucum and Tripterygium wilfordii, inhibits HIV replication in H9 lymphocytes with an EC50 value of <0.10 μg/mL[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[References]

[1]. Duan H, et al. Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents. J Nat Prod. 2000 Mar;63(3):357-61.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1003.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₆H₄₉NO₂₂

[ Molecular Weight ]:
961.912

[ Flash Point ]:
560.6±34.3 °C

[ Exact Mass ]:
961.321594

[ PSA ]:
316.35000

[ LogP ]:
1.51

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds

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