4-Phenyl-1H-1,2,3-triazole

Names

[ Name ]:
4-Phenyl-1H-1,2,3-triazole

[Synonym ]:
1H-1,2,3-Triazole, 4-phenyl-
4-Phenyl-1H-1,2,3-triazole
5-phenyl-1h-1,2,3-triazole

Biological Activity

[Description]:

4-Phenyl-1H-1,2,3-triazole is an IDO1 inhibitor (IC50: 60 渭M). 4-Phenyl-1H-1,2,3-triazole can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[References]

[1]. Röhrig UF, et al. Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem. 2012 Jun 14;55(11):5270-90.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
346.0±11.0 °C at 760 mmHg

[ Melting Point ]:
143-14℃

[ Molecular Formula ]:
C₈H₇N₃

[ Molecular Weight ]:
145.16

[ Flash Point ]:
169.4±12.2 °C

[ Exact Mass ]:
145.063995

[ PSA ]:
41.57000

[ LogP ]:
1.91

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.611

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%