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Terpendole I

Names

[ CAS No. ]:
167612-17-1

[ Name ]:
Terpendole I

[Synonym ]:
2H,4bH-Oxireno[4',4a']-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b-diol, 3,3a,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2S,3R,3aR,4aS,4bS,6aS,12bS,12cR,14aS)-
Terpendole I
(2S,3R,3aR,4aS,4bS,6aS,12bS,12cR,14aS)-2-(2-Hydroxy-2-propanyl)-12b,12c-dimethyl-3,3a,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2H,4bH-oxireno[4',4a']chromeno[5',6':6,7]indeno[1,2-b]indole-3,4b-diol

Biological Activity

[Description]:

Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 µM)[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Microbial Metabolite


[References]

[1]. Tomoda H, et al. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J Antibiot (Tokyo). 1995;48(8):793-804.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
668.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H35NO5

[ Molecular Weight ]:
453.570

[ Flash Point ]:
358.0±31.5 °C

[ Exact Mass ]:
453.251526

[ LogP ]:
4.51

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.681

Related Compounds