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CT-2584

Names

[ CAS No. ]:
166981-13-1

[ Name ]:
CT-2584

[Synonym ]:
1-(11-(dodecylamino)-10-hydroxyundecyl)-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione
CT-2584
1-(11-Dodecylamino-10-hydroxylundecyl)-3,7-dimethylxanthine
1-(11-(dodecylamino)-10-hydroxyundecyl)-3,7-dimethylxanthine
1H-Purine-2,6-dione,1-(11-(dodecylamino)-10-hydroxyundecyl)-3,7-dihydro-3,7-dimethyl

Biological Activity

[Description]:

CT-2584 is a chemotherapeutic compound that reduces the expression of NKEF-B in several tumor cell types and kills tumor cells by inducing the production of ROS in mitochondria, commonly used in cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

CT-2584 (0-7 μM, 3 days) 对 ECV304 具有一定的毒性作用，而 B/1 细胞对此具有较强的抵抗力[1]。 Cell Viability Assay[1] Cell Line: ECV304 and its derived cell lines Concentration: 0-7 μM Incubation Time: 3 days Result: Inhibited ECV304 and B/1 cells with the LC50 value of 4.5 μ M and 6.5 μ M,respectively. After 7 μM treatment, the shape of ECV304 or ECV304/pCE2 cells became round and detached from the plate, while B/1 cells could clearly observe living cells that retained the spindle shape.

[References]

[1]. H Shau, et al. Endogenous natural killer enhancing factor-B increases cellular resistance to oxidative stresses. Free Radic Biol Med. 1997;22(3):497-507.  

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
691.4ºC at 760mmHg

[ Molecular Formula ]:
C30H55N5O3

[ Molecular Weight ]:
533.79

[ Flash Point ]:
371.9ºC

[ Exact Mass ]:
533.43000

[ PSA ]:
94.08000

[ LogP ]:
5.81680

Related Compounds