Anhydrotetracyclin

Names

[ CAS No. ]:
1665-56-1

[ Name ]:
Anhydrotetracyclin

[Synonym ]:
5a,6-Anhydrotetracycline
Anhydrotetracyclin

Biological Activity

[Description]:

Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

Tetracycline inactivating enzyme[1]

[In Vitro]

体外实验表明，Anhydrotetracycline (0.1 μM-10 mM) 对四环素破坏酶具有剂量依赖性和强抑制作用[1]。

[References]

[1]. Markley JL, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633.

Chemical & Physical Properties

[ Density]:
1.6 g/cm3

[ Boiling Point ]:
618.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₂N₂O₇

[ Molecular Weight ]:
426.41900

[ Flash Point ]:
327.9ºC

[ Exact Mass ]:
426.14300

[ PSA ]:
161.39000

[ LogP ]:
1.15610

[ Vapour Pressure ]:
3.66E-16mmHg at 25°C

[ Index of Refraction ]:
1.76

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9277520

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-diox o-6-methyl- 3,10,11,12a-tetrahydroxy-, (4S-(4-alpha,4a-alpha,12a-alpha))-

CAS REGISTRY NUMBER :: 1665-56-1

LAST UPDATED :: 199009

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H22-N2-O7

MOLECULAR WEIGHT :: 426.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 134 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 20 mg/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,403,1974

Safety Information

[ Hazard Codes ]:
T

Precursor & DownStream

Precursor

DownStream

Related Compounds

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