Anhydrotetracyclin
Names
[ CAS No. ]:
1665-56-1
[ Name ]:
Anhydrotetracyclin
[Synonym ]:
5a,6-Anhydrotetracycline
Anhydrotetracyclin
Biological Activity
[Description]:
Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro[1].
[Related Catalog]:
[Target]
Tetracycline inactivating enzyme[1]
[In Vitro]
体外实验表明，Anhydrotetracycline (0.1 μM-10 mM) 对四环素破坏酶具有剂量依赖性和强抑制作用[1]。
[References]
Chemical & Physical Properties
[ Density]:
1.6 g/cm3
[ Boiling Point ]:
618.6ºC at 760 mmHg
[ Molecular Formula ]:
C22H22N2O7
[ Molecular Weight ]:
426.41900
[ Flash Point ]:
327.9ºC
[ Exact Mass ]:
426.14300
[ PSA ]:
161.39000
[ LogP ]:
1.15610
[ Vapour Pressure ]:
3.66E-16mmHg at 25°C
[ Index of Refraction ]:
1.76
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9277520
- CHEMICAL NAME :
- 2-Naphthacenecarboxamide, 1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-diox o-6-methyl- 3,10,11,12a-tetrahydroxy-, (4S-(4-alpha,4a-alpha,12a-alpha))-
- CAS REGISTRY NUMBER :
- 1665-56-1
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C22-H22-N2-O7
- MOLECULAR WEIGHT :
- 426.46
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 134 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,403,1974
Safety Information
[ Hazard Codes ]:
T