N-Boc-PEG3-bromide

Names

[ Name ]:
N-Boc-PEG3-bromide

[Synonym ]:
Carbamic acid, N-[2-[2-(2-bromoethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
tert-butyl N-[2-[2-(2-bromoethoxy)ethoxy]ethyl]carbamate
2-Methyl-2-propanyl {2-[2-(2-bromoethoxy)ethoxy]ethyl}carbamate

Biological Activity

[Description]:

N-Boc-PEG3-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Alex Cortez, et al. Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
382.8±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₂BrNO₄

[ Molecular Weight ]:
312.201

[ Flash Point ]:
185.3±23.7 °C

[ Exact Mass ]:
311.073212

[ PSA ]:
60.28000

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.472

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

N-Boc-PEG3-bromide

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds