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Fmoc-NH-PEG1-C2-acid

Names

[ CAS No. ]:
1654740-73-4

[ Name ]:
Fmoc-NH-PEG1-C2-acid

[Synonym ]:
MFCD16294357
Propanoic acid, 3-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]-
3-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethoxy)propanoic acid
Fmoc-6-Amino-4-oxahexanoic acid

Biological Activity

[Description]:

Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
589.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H21NO5

[ Molecular Weight ]:
355.384

[ Flash Point ]:
310.6±27.3 °C

[ Exact Mass ]:
355.141968

[ LogP ]:
3.37

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.589

Related Compounds