Muscotoxin A

Names

[ Name ]:
Muscotoxin A

Biological Activity

[Description]:

Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[In Vitro]

Muscotoxin A (0-13.2 μM ; 24 hours) is cytotoxic to YAC-1, Sp/2, and HeLa cancer cell lines (LC50) ranged from 9.9 to 13.2 μM, causing membrane damage and influx of calcium ions[1].

[References]

[1]. Petr Tomek, et al. Cytotoxic Lipopeptide Muscotoxin A, Isolated From Soil Cyanobacterium Desmonostoc Muscorum, Permeabilizes Phospholipid Membranes by Reducing Their Fluidity. Chem Res Toxicol. 2015 Feb 16;28(2):216-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₈H₉₀N₁₂O₁₆

[ Molecular Weight ]:
1211.41

Related Compounds

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