SX-682

Names

[ Name ]:
SX-682

[Synonym ]:
MFCD28502254

Biological Activity

[Description]:

SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR1

CXCR2

[References]

[1]. Sun L, et al. Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy. JCI Insight. 2019 Apr 4;4(7).

Chemical & Physical Properties

[ Density]:
1.53±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₁₉H₁₄BF₄N₃O₄S

[ Molecular Weight ]:
467.20

Related Compounds

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