Podophyllotoxin β-D-glucoside

Names

[ Name ]:
Podophyllotoxin β-D-glucoside

[Synonym ]:
Podophyllotoxin-7-O-glucoside
Podophyllotoxin 4-O-glucoside
(5R,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl β-D-glucopyranoside
Podophyllotoxin glucoside
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-(β-D-glucopyranosyloxy)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-
Podophyllotoxin, 3-β-D-glucopyranoside
Podophyllotoxin-4-O-glucoside
Podophyllotoxin-β-D-glucoside

Biological Activity

[Description]:

Podophyllotoxin glucoside is a podophyllotoxin derivative, has anti-tumor effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. K R Hande, et al. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
781.3±60.0 °C at 760 mmHg

[ Melting Point ]:
152-154℃

[ Molecular Formula ]:
C₂₈H₃₂O₁₃

[ Molecular Weight ]:
576.546

[ Flash Point ]:
258.2±26.4 °C

[ Exact Mass ]:
576.184265

[ PSA ]:
171.83000

[ LogP ]:
-0.66

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.660

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP9002050

CHEMICAL NAME :: Podophyllotoxin, 4,6-O-benzylidene-beta-D-glucopyranoside

CAS REGISTRY NUMBER :: 16481-54-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C28-H32-O13

MOLECULAR WEIGHT :: 576.60

WISWESSER LINE NOTATION :: T E5 C665 FVO NO PO OHTT&&J DR CO1 DO1 EO1& JO- HT66 BO DO GOTJ CR& IQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 30 mg/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,2998,1977

Precursor & DownStream

Precursor

DownStream

Related Compounds

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