Tomuzotuximab

Names

[ Name ]:
Tomuzotuximab

Biological Activity

[Description]:

Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vitro]

Tomuzotuximab has a fully human glycosylation pattern and is glyco-optimised at its Fc domain, while fully retaining the affinity, specificity, EGFR inhibition and induction of apoptosis of Cetuximab[1].

[References]

[1]. Waer Fiedler, et al. Phase I study of tomuzotuximab, a glycoengineered therapeutic antibody against the epidermal growth factor receptor, in patients with advanced carcinomas. ESMO Open. 2018 Feb 1;3(2):e000303.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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