THZ-2-118

Names

[ Name ]:
THZ-2-118

Biological Activity

[Description]:

THZ-2-118 is a potent selective inhibitor of IRAK1 with IC50 of 14.2 nM;THZ-2-118 does not inhibitor IRAK4 at 10 uM, also potently inhibits JNK1/2/3 (IC50=1-2 nM).

[References]

1. Hatcher JM, et al. ACS Med Chem Lett. 2020 Oct 9;11(11):2238-2243.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₇N₇O₂

[ Molecular Weight ]:
493.571

Related Compounds

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