Fmoc-D-Trp(Boc)-OH

Names

[ Name ]:
Fmoc-D-Trp(Boc)-OH

[Synonym ]:
1-(tert-Butoxycarbonyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tryptophan
Nalpha-Fmoc-N(in)-Boc-D-tryptophan
AmbotzFAA1339
Fmoc-D-Trp(Boc)
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-tryptophan
D-Tryptophan, 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
Fmoc-D-Trp(Boc)-OH
N|A-Fmoc-N(in)-Boc-D-tryptophan
Fmoc-L-Trp(Boc)-OH
MFCD00153367
(2R)-3-{1-[(tert-butoxy)carbonyl]-1H-indol-3-yl}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoic acid

Biological Activity

[Description]:

Fmoc-D-Trp(Boc)-OH is a cleavable ADC linker that used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
86 - 92ºC (Decomposes)

[ Molecular Formula ]:
C₃₁H₃₀N₂O₆

[ Molecular Weight ]:
526.580

[ Exact Mass ]:
526.210388

[ PSA ]:
106.86000

[ LogP ]:
7.05

[ Index of Refraction ]:
1.632

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Solid-phase synthesis of C-terminal azapeptides.

J. Pept. Sci. 21 , 387-91, (2015)

The solid-phase synthesis of azapeptides possessing a C-terminal aza-residue has been accomplished by a protocol featuring regioselective alkylation of benzhydrylidene-aza-glycinamide and illustrated ...

Related Compounds

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