tetrathiomolybdate

Names

[ Name ]:
tetrathiomolybdate

Biological Activity

[Description]:

Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vivo]

Tetrathiomolybdate (0.2 mg/小鼠/天; 口服; 10 周)保护小鼠免受胶原诱导的关节炎，具有预防作用[1]。 Tetrathiomolybdate (0.03 mg/mL; 加在水中，8 周)通过减少肿胀和红斑抑制小鼠胶原诱导关节炎的进展[1]。 Animal Model: Collagen-induced arthritis model in mice[1] Dosage: 0.2 mg/mouse/day or 0.03 mg/mL, added in water Administration: Oral gavage, for 10 weeks; Collagen injected at weeks 2 Result: Showed significant preventive effect and protective effect in mice.

[References]

[1]. Zeng C, et al. Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. Exp Biol Med (Maywood). 2008 Aug;233(8):1021-5.

Chemical & Physical Properties

[ Molecular Formula ]:
MoS₄--

[ Molecular Weight ]:
224.22000

[ Exact Mass ]:
225.79400

[ PSA ]:
64.18000

[ LogP ]:
1.29160

Related Compounds

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