URAT1 inhibitor 7

Names

[ CAS No. ]:
1632002-28-8

[ Name ]:
URAT1 inhibitor 7

Biological Activity

[Description]:

URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC50 of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 µL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC50 of 4.2 μM. URAT1 inhibitor 7 can be used for gout research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1

Research Areas >> Inflammation/Immunology

[References]

[1]. Storer R I, et al. The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm, 2016:10.1039.C6MD00190D.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₀ClFN₄O₃S

[ Molecular Weight ]:
428.82

URAT1 inhibitor 7

Names

Biological Activity

Chemical & Physical Properties

Related Compounds