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Itacnosertib

Names

[ CAS No. ]:
1628870-27-8

[ Name ]:
Itacnosertib

[Synonym ]:
(6E)-6-(2,2'-Bipyridin-3-ylimino)-N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1,6-dihydro-2-pyrimidinamine
2-Pyrimidinamine, 6-([2,2'-bipyridin]-3-ylimino)-1,6-dihydro-N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-, (6E)-

Biological Activity

[Description]:

Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[References]

[1]. Mollard, Alexis; Warner, Steven L.; Flynn, Gary A.; Vankayalapati, Hariprasad; Bearss, David J. Preparation of [(piperazinylphenyl)amino]pyrimidine derivatives as JAK2 and ALK2 inhibitors. WO2014151871 A2

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
675.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H28N8O

[ Molecular Weight ]:
468.55

[ Flash Point ]:
362.2±34.3 °C

[ Exact Mass ]:
468.238617

[ LogP ]:
3.36

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.679

Related Compounds