FGFR4-IN-2

Names

[ Name ]:
FGFR4-IN-2

Biological Activity

[Description]:

FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC.

[References]

1. Haibo Liu, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₃Cl₂N₅O₅

[ Molecular Weight ]:
520.367

Related Compounds

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