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Polygalaxanthone III

Names

[ CAS No. ]:
162857-78-5

[ Name ]:
Polygalaxanthone III

[Synonym ]:
D-Glucitol, 1,5-anhydro-6-O-[(2R,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-1-C-(1,3,6-trihydroxy-7-methoxy-9-oxo-9H-xanthen-2-yl)-, (1S)-
(1S)-1,5-Anhydro-6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-1-(1,3,6-trihydroxy-7-methoxy-9-oxo-9H-xanthen-2-yl)-D-glucitol
polygalaxanthone III

Biological Activity

[Description]:

Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards CYP450 enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Inflammation/Immunology

[References]

[1]. Li ZL, et al. Effect of oligosaccharide esters and polygalaxanthone Ill from Polygala tenuifolia willd towards cytochrome P450. Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4459-63.

Chemical & Physical Properties

[ Density]:
1.83

[ Boiling Point ]:
973.2±65.0 °C at 760 mmHg

[ Melting Point ]:
180-183℃

[ Molecular Formula ]:
C25H28O15

[ Molecular Weight ]:
568.481

[ Flash Point ]:
327.7±27.8 °C

[ Exact Mass ]:
568.142822

[ LogP ]:
-0.31

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.765

Safety Information

[ Safety Phrases ]:
S24/25

Related Compounds