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PKR-IN-2

Names

[ CAS No. ]:
1628428-01-2

[ Name ]:
PKR-IN-2

[Synonym ]:
5-Quinoxalinesulfonamide, N-[4-[[4-hydroxy-4-(2-methylpropyl)-1-piperidinyl]carbonyl]phenyl]-
WLI3QP8XYK
N-{4-[(4-Hydroxy-4-isobutyl-1-piperidinyl)carbonyl]phenyl}-5-quinoxalinesulfonamide

Biological Activity

[Description]:

PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of ＜100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value: ＜100 nM (AC50)Target: PKR

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. Popovici-Muller, et al. Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918.

[2]. Cianchetta Giovanni, et al. Preparation of aroylpiperidines, particularly arysulfonylamino and heteroarylsulfonylamino substituted, as pyruvate kinase PKM2 modulators useful in the treatment of cancer and compositions containing them. From PCT Int. Appl.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
681.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H28N4O4S

[ Molecular Weight ]:
468.569

[ Flash Point ]:
365.9±34.3 °C

[ Exact Mass ]:
468.183136

[ LogP ]:
1.12

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
2-8℃

Related Compounds