ARN 726

Names

[ Name ]:
ARN 726

[Synonym ]:
compound 6 [PMID: 25874594]
Carbamic acid, N-[(3S)-2-oxo-3-azetidinyl]-, 4-cyclohexylbutyl ester
4-Cyclohexylbutyl [(3S)-2-oxo-3-azetidinyl]carbamate

Biological Activity

[Description]:

ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA); shows no interaction with a panel of 28 biologically relevant targets comprising lipid-metabolizing and inflammation-related enzymes; exerts profound anti-inflammatory effects in both mouse models and human macrophages.

[References]

References 1. Ribeiro A, et al. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. 2. Bonezzi FT, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):656-63. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
478.8±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₄N₂O₃

[ Molecular Weight ]:
268.352

[ Flash Point ]:
243.4±25.7 °C

[ Exact Mass ]:
268.178680

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.515

Related Compounds

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