kaempferoltetraacetate

Names

[ Name ]:
kaempferoltetraacetate

[Synonym ]:
4H-1-Benzopyran-4-one, 3,5,7-tris(acetyloxy)-2-[4-(acetyloxy)phenyl]-
2-(4-Acetoxyphenyl)-4-oxo-4H-chromene-3,5,7-triyl triacetate

Biological Activity

[Description]:

Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Kaempferol tetraacetate (compound 1a) (0-100 µM; 72 h) 显示细胞毒性，对 HL-60、U937、SK-MEL-1 细胞的 IC50 值分别为 45、48、37 µM [2]。 Cell Cytotoxicity Assay[2] Cell Line: HL-60, U937, SK-MEL-1 cells Concentration: 0-100 µM Incubation Time: 72 h Result: Showed cytotoxicity with IC50s of 45, 48, 37 µM for HL-60, U937, SK-MEL-1 cells, respectively.

[References]

[1]. Mei Q, et al. Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates. Beilstein J Org Chem. 2015 Feb 25;11:288-93.

[2]. Díaz JG, et al. Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Planta Med. 2008 Feb;74(2):171-4.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
609.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₈O₁₀

[ Molecular Weight ]:
454.383

[ Flash Point ]:
263.9±31.5 °C

[ Exact Mass ]:
454.089996

[ PSA ]:
135.41000

[ LogP ]:
1.16

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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