Glycopyrronium tosylate

Glycopyrronium tosylate an anticholinergic compound used in the treatment of axillary hyperhidrosis for the study of a variety of cryptobacterial tumors.

Glycopyrronium tosylate (GT) reduced sweating severity and production versus vehicle and was generally well tolerated. Improvement was substantially greater for GT than for vehicle at every study week, and, at week 4, ASDD scores improved from baseline by 62.6 versus 34.0% (severity), 65.5 versus 40.3% (impact), and 65.4 versus 39.0% (bothersomeness). Improvements favoring GT versus vehicle also occurred for WI items, PGIC, HDSS, and DLQI.[2]

1. Yokozeki H, et al. Topical glycopyrronium tosylate in Japanese patients with primary axillary hyperhidrosis: A randomized, double-blind, vehicle-controlled study. J Dermatol. 2022;49(1):86-94.