Naratuximab

Names

[ Name ]:
Naratuximab

Biological Activity

[Description]:

Naratuximab (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) is a humanized monoclonal antibody that binds CD37 (TSPAN26). Naratuximab can be used to synthesize an ADC compound, Naratuximab emtansine[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Naratuximab emtansine (IMGN529)，一种 ADC，由 DM1 通过与 Kadcyla 中使用的相同接头连接到人源化抗 CD37 抗体组成。 Naratuximab emtansine 有效地将其抗体成分的内在促凋亡和效应活性与美登木素有效载荷的细胞毒活性结合起来[1]。

[References]

[1]. Stuart W Hicks, et al. The Antitumor Activity of IMGN529, a CD37-Targeting Antibody-Drug Conjugate, Is Potentiated by Rituximab in Non-Hodgkin Lymphoma Models. Neoplasia. 2017 Sep;19(9):661-671.

Chemical & Physical Properties

No Any Chemical & Physical Properties