Biotin-PEG12-acid

Names

[ Name ]:
Biotin-PEG12-acid

[Synonym ]:
41-Oxo-45-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-40-azapentatetracontan-1-oic acid
4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxa-40-azapentatetracontan-1-oic acid, 45-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-41-oxo-

Biological Activity

[Description]:

Biotin-PEG12-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
932.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₇H₆₉N₃O₁₆S

[ Molecular Weight ]:
844.019

[ Flash Point ]:
517.9±34.3 °C

[ Exact Mass ]:
843.439880

[ LogP ]:
-4.63

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.496

Related Compounds

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