VPC 14449

Names

[ Name ]:
VPC 14449

[Synonym ]:
MFCD29477380
Morpholine, 4-[4-(4,5-dibromo-1H-imidazol-1-yl)-2-thiazolyl]-
4-[4-(4,5-Dibromo-1H-imidazol-1-yl)-1,3-thiazol-2-yl]morpholine

Biological Activity

[Description]:

VPC 14449 is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM, without affecting AR protein expression; effectively blocks transcriptional activity of full-length and splice variant AR forms at low to sub-micromolar concentrations; reduces tumor volume and abolishes PSA production in LNCaP xenograft model.

[References]

References 1. Dalal K, et al. Mol Cancer Ther. 2017 Aug 3. pii: molcanther.0259.2017. 2. Dalal K, et al. J Biol Chem. 2014 Sep 19;289(38):26417-29. View Related Products by Target Androgen Receptor (AR)

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
542.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₀Br₂N₄OS

[ Molecular Weight ]:
394.086

[ Flash Point ]:
282.1±32.9 °C

[ Exact Mass ]:
391.894196

[ LogP ]:
0.93

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.802

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.