SHP2 inhibitor 11a-1

A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs; specifically attenuates the SHP2-dependent signaling in cell; blocks growth factor mediated Erk1/2 and Akt activation and exhibits excellent antiproliferative activity in lung cancer and breast cancer as well as leukemia cell lines; ameliorates the pathogenesis of systemic lupus erythematosus in mice.

References 1. Zeng LF, et al. J Med Chem. 2014 Aug 14;57(15):6594-609. 2. Wang J, et al. J Clin Invest. 2016 Jun 1;126(6):2077-92. View Related Products by Target Protein Phosphatase/PTP