4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

Names

[ CAS No. ]:
162046-66-4

[ Name ]:
4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

[Synonym ]:
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid
1-Piperazinecarboxylic acid, 4-(4-carboxyphenyl)-, 1-(1,1-dimethylethyl) ester
4-(4-Carboxyphenyl)piperazine-1-carboxylic acid tert-butyl ester
4-(4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)benzoic acid
MFCD04115067
4-(4-Carboxy-phenyl)-piperazine-1-c; arboxylic acid tert-butyl ester
4-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic acid

Biological Activity

[Description]:

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer[1].

[References]

[1]. Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
476.9±40.0 °C at 760 mmHg

[ Melting Point ]:
50ºC

[ Molecular Formula ]:
C₁₆H₂₂N₂O₄

[ Molecular Weight ]:
306.357

[ Flash Point ]:
242.2±27.3 °C

[ Exact Mass ]:
306.157959

[ PSA ]:
70.08000

[ LogP ]:
1.93

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.561

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
22-26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%