Depreotide

Names

[ CAS No. ]:
161982-62-3

[ Name ]:
Depreotide

[Synonym ]:
(2S,5R,8S,11S)-11-Amino-2,8-bis(4-aminobutyl)-18-[(2S,5S,8S,11R,14S,17S)-14-(4-aminobutyl)-5-benzyl-8-(4-hydroxybenzyl)-11-(1H-indol-3-ylmethyl)-17-isopropyl-4-methyl-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexaazacyclooctadecan-2-yl]-4,7,10,14-tetraoxo-5-(sulfanylmethyl)-16-thia-3,6,9,13-tetraazaoctadecan-1-amide
Cyclo(L-homocysteinyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl) (1®1')-Sulfide with 3-(2-Mercaptoacetamido)-L-alanyl-L-lysyl-L-cysteinyl-L-lysinamide
Depreotide
Cyclo[S-[(5S,8S,11R,14S)-5,18-diamino-8-(4-aminobutyl)-14-(aminocarbonyl)-11-(mercaptomethyl)-2,6,9,12-tetraoxo-3,7,10,13-tetraazaoctadec-1-yl]-L-homocysteyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl]
NeoTect
Cyclo(L-homocysteinyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl) (1-1')-thioether with 3-[(2-mercaptoacetyl)amino]-L-alanyl-L-lysyl-L-cysteinyl-L-lysinamide

Biological Activity

[Description]:

Depreotide is a nove tumor tarcer, can be complexed with technetium-99m (99mTc-depreotide) for optimal imaging properties. 99mTc-depreotide somatostain receptor imaging has been playing an important role in medical diagnosis research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Depreotide, complexed with technetium-99m to form (99m)Tc-depreotide, binds somatostatin receptors (SSTRs) with high affinity to SSTRs 2, 3, and 5[1].

[In Vivo]

99mTc-depreotide (sodium chloride 0.9% w/v solution; i.v.; single dose) shows a optimal image interpretation with SPECT images (Single Photon Emission Computed Tomography) between 2 and 4 hours following injection[2].

[References]

[1]. Rodrigues M, et al. 99mTc-depreotide scintigraphy versus 18F-FDG-PET in the diagnosis of radioiodine-negative thyroid cancer. J Clin Endocrinol Metab. 2006 Oct;91(10):3997-4000.

[2]. Halley A, et al. Efficiency of 18F-FDG and 99mTc-depreotide SPECT in the diagnosis of malignancy of solitary pulmonary nodules. Eur J Nucl Med Mol Imaging. 2005 Sep;32(9):1026-32.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1654.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆₅H₉₆N₁₆O₁₂S₂

[ Molecular Weight ]:
1357.688

[ Flash Point ]:
954.2±34.3 °C

[ Exact Mass ]:
1356.683472

[ LogP ]:
-1.03

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.582

Related Compounds

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