GUT-70

GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB.

References 1. Kimura S, et al. Int J Cancer. 2005 Jan 1;113(1):158-65. 2. Jin L, et al. Br J Cancer. 2011 Jan 4;104(1):91-100. 3. Kudo E, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9. View Related Products by Target Apoptosis Inducer