TCO-PEG4-NHS ester

Names

[ Name ]:
TCO-PEG4-NHS ester

[Synonym ]:
(4Z)-4-Cycloocten-1-yl {15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}carbamate
Carbamic acid, N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-, (4Z)-4-cycloocten-1-yl ester
MFCD28118912

Biological Activity

[Description]:

TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[References]

[1]. Jung S, et al. An integrated approach for enhanced protein conjugation and capture with viral nanotemplatesand hydrogel microparticle platforms via rapid bioorthogonal reactions. Langmuir. 2014 Jul 8;30(26):7762-70.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₃₈N₂O₁₀

[ Molecular Weight ]:
514.566

[ Exact Mass ]:
514.252625

[ LogP ]:
-0.09

[ Index of Refraction ]:
1.525

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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