Ruzasvir

Names

[ Name ]:
Ruzasvir

[Synonym ]:
LX752BD95Y
UNII:LX752BD95Y
Carbamic acid, N,N'-[[(6S)-6-(2-cyclopropyl-5-thiazolyl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, dimethyl ester
Methyl {(2S)-1-[(2S)-2-{5-[(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-3-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-5-yl}indolo[1,2-c][1,3]benzoxazin-10-yl]-1H-imidazol-2-yl}-1-pyrrolidinyl]-3-methyl-1-oxo-2-butanyl}carbamate
ruzasvir
MFCD30829910

Biological Activity

[Description]:

A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively. HCV Infection Phase 2 Clinical

[References]

References 1. Tong L, et al. J Med Chem. 2017 Jan 12;60(1):290-306. 2. Wyles D, et al. Hepatology. 2017 Dec;66(6):1794-1804. 3. Lawitz E, et al. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):814-823. View Related Products by Target HCV HCV Infection

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₄₉H₅₅FN₁₀O₇S

[ Molecular Weight ]:
947.087

[ Exact Mass ]:
946.395996

[ LogP ]:
6.30

[ Index of Refraction ]:
1.742

Related Compounds

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